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With the Industriepark Höchst, the airport and the Osthafen, Frankfurt am Main has several major workplaces for industry, logistics and engineering. Around 20,000 people work for roughly 90 companies in the Industriepark, and in the east Deutsche Bahn has been building the Nordmainische S-Bahn to Maintal and Hanau since 2025. The A3 and A5 meet at the Frankfurter Kreuz, and the Hauptbahnhof is a hub for ICE and S-Bahn services.
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In the west, the Industriepark Höchst spans the districts of Höchst, Sindlingen and Schwanheim. On 460 hectares, around 20,000 people work for roughly 90 companies in chemicals, pharmaceuticals and biotechnology, the largest of which is Sanofi. In the east are the Osthafen with its container terminal and the Fechenheim-Nord/Seckbach industrial and commercial area. Terminal 3 opened at the airport in April 2026, and from 2030 Terminal 2 is due to be refurbished and converted for around 1.5 billion euros. The A3 and A5 meet at the Frankfurter Kreuz, the A66 has the Frankfurt-Höchst and Frankfurt-Miquelallee junctions in the west, and the A661 has Frankfurt-Ost and others in the east. Eight of the nine S-Bahn lines run through the City-Tunnel, and the S8 and S9 connect the Hauptbahnhof and the airport.
The S-Bahn lines S8 and S9 run from the Hauptbahnhof to the airport and continue towards Mainz and Wiesbaden. For ICE trains, the airport has its own long-distance station.
The A3 and A5 cross at the Frankfurter Kreuz near the airport. In addition there are the A66 towards Wiesbaden and Fulda, the A661 from Oberursel to Egelsbach, and the short A648, which feeds into the Messe and the city centre. Together, the A5, A661 and A3 form a motorway ring around the city.
The Industriepark Höchst is in the west, and the S-Bahn (S1 and S2) stops at Frankfurt-Höchst Farbwerke station by the Tor Nord gate. In the east are the Osthafen near the A661 and the Fechenheim-Nord/Seckbach industrial and commercial area, and in the south is the airport.